Multivariate regression analysis based on the Cox proportional hazards regression model demonstrated that the cyclin D1 status (hazard ratio=0.630;P=0.035), differentiation (hazard ratio=0.399; P < 0.001), and pTNM (hazard ratio=1.576; P < 0.001) were independent prognostic factors for NSCLC patients (Tab 3). This evidence concerns the gene CCND1 and non-small cell lung carcinoma.