We hypothesized that if the induction of the PI3K/AKT pathway by LMP2A contributes to 5-FU resistance in EBV-positive gastric cancer cells, the combination of 5-FU with specific inhibitors of the PI3K pathway may result in a synergistic effect in EBV-positive gastric cancer cell lines, such as SNU-719 cells. Here, AKT1 is linked to gastric cancer.