The expressions of p16, p21, p27 and p53 were statistically significantly higher in pGSK-3β positive gastric carcinomas than in pGSK-3β negative carcinomas (P < 0.001, P < 0.001, P = 0.001, and P = 0.013, respectively). The gene discussed is CDKN1B; the disease is gastric carcinoma.