LEP and Insulin resistance: Improved functioning-Jess self-neglect, improved eating habitsIncrease in appetite-eaibohydrate craving, sedation and decreased motor activityAltered adipose tissue-Hetabolism, fat composition (brown/white/adipose tissue) and distributionNeurotransnitter effects due to serotonineigic, histamineigic,14 dopanineigic, adreneigic (alpha- 1) receptor blockade or a combination of these67Increase in the leptin level1516Hyperinsulinaemia, hyperlipidaemia, insulin resistance and hyperleptinaemia may be associated with weight gain3Increase in prolactin level17