SOAT1 and arthritic joint disease: Although we did not directly evaluate inhibition of JAK2 or in vitro granulopoiesis in the rat, inhibition of arthritis, cytokines and neutrophilia in the AIA model were observed at plasma exposures that were well below the human JAK2 IC50 and effects on GM-CSF stimulated STAT phosphorylation in the rat whole blood assay.