MITF and melanoma: More and more evidence indicates that MiTF plays multiple roles in melanomagenesis including stimulating angiogenesis via activating Hif1α [8], enhancing cell proliferation via activating transcription of Bcl-2 and CDK2 [9,10], preventing apoptosis via activating melanoma inhibitor of apoptosis (ML-IAP) [11], inhibiting invasion via activating DIAPH-1 [12], and promoting survival after elevation of cellular reactive oxygen species via activating Ape/Ref-1 [13].