As shown in Fig 4D, three melanoma cell lines (A375, 1205Lu and WM3211) which accumulated undetectable MiTF protein [13] showed higher cell death (19% to 26%) as compared to three MiTF-positive melanoma cell lines (Malme-3 M, SK-Mel-28 and c83-2C) (4% to 10%) (Fig 4D and 4E). This evidence concerns the gene MITF and melanoma.