The 26 genes that remain include 10 pseudogenes or processed transcripts with no known protein products; two genes of potential functional relevance to angiogenesis or TGF-β signalling (FGF1 and PPP2R2B); three protein coding genes associated with other genetic disease (ARHGAP26; NR3C1 and POU4F3) and 11 protein coding genes not associated with a genetic disease but whose gene product had no obvious function in TGF-β signalling and/or angiogenesis (HMHB1; YIPF5; KCTD16; PRELID2; LARS; TCERG1; SH3RF2; GRXCR2; RBM27; PLAC8L1 and GPR151). This evidence concerns the gene KCTD16 and hereditary disease.