PREDICT is focusing on four recently identified research priority areas: first, identification of predictive and surrogate biomarkers, which will help select patients for particular therapies and provide early information on treatment efficacy; second, determination of the mechanisms of acquired resistance to VEGF-targeted therapy; third, determination of mechanisms of response to current agents, with a particular emphasis on how this might lead to the development of more effective agents and more rational treatment sequencing; and fourth, identification of new targets in RCC. Here, VEGFA is linked to renal cell carcinoma.