KCNQ1 and type 2 diabetes mellitus: Only recently have scholars demonstrated that the increased risk for T2DM linked to SNPs in KCNQ1 is likely to be caused by a reduction in insulin secretion, higher levels of fasting glucose or HbA1c [5,9,10], which implies that the KCNQ1 variants may play a major physiological role in the metabolism and dynamic balance of blood glucose.