In the current study, subjects in 3 groups according to different genotypes at rs2283228, rs2237895, rs2237897, and rs2237892 were well matched for mean age and gender composition, and no significant differences were detected in the prevalences of hypertension, T2DM, family history of CAD, smoking and values of BMI, FBS, insulin, TC, LDL-C, and HOMA-IR. This evidence concerns the gene INS and hypertensive disorder.