NKX2-1 and thyroid gland carcinoma: In conclusions, in this study we analyzed 63 FPTC patients for the presence of the A339V mutation in thyroid transcription factor-1 (TITF-1/NKX2.1) in order to correlate that mutation with the predisposition to develop familial form of thyroid cancer demonstrated by shorter telomere length which may contribute to genetic instability and thyroid cancer development.