CASP3 and neoplasm: Immunohistochemical (IHC) analysis of cleaved caspase 3 (Figure 2A and supplemental Figure S2A), a marker for apoptotic cells; Ki-67 (Figures 2A, B and supplemental Figures S2A, B), a marker for mitotic cells; and MECA-32 (Figures 2A, C and supplemental Figures S2A, C), an endothelial cell maker, showed that adiponectin deficiency in mice had no effect on tumor cell apoptosis, mitosis, or angiogenesis.