As shown in supplemental Figure S1, although purified mouse recombinant adiponectin could inhibit MDA-MB-231 cell proliferation at a concentration of 30 μg/ml, the same recombinant protein had no effect on B16F10 cell proliferation in vitro, suggesting that the inhibitory effects of adiponectin on cell proliferation are cell-type dependent and that other mechanisms by which adiponectin deficiency promotes tumor growth in mice are yet to be identified. This evidence concerns the gene ADIPOQ and neoplasm.