Mice (p48-Cre:LSL-KrasG12D:p16ink4a/arf+/lox) expressing a pancreas-specific Cre recombinanse activating a constitutively active Kras allele (KrasG12D) and inactivating a single copy of Ink4a/Arf that spontaneously develop pancreatic ductal adenocarcinoma (PDAC) [17] were separated into three groups receiving either saline, mouse chimeric r84 (mcr84 [21]), or sunitinib. Here, KRAS is linked to pancreatic ductal adenocarcinoma.