Since hypertension and proteinuria are among the most common toxicity-related side effects associated with anti-VEGF therapy and given recent data suggesting a role for VEGFR2 in controlling blood pressure [13], [26], we investigated the effects of r84 therapy on hypertension and proteinuria in a spontaneous, immunocompetent model of pancreatic cancer. The gene discussed is VEGFA; the disease is familial pancreatic carcinoma.