Additionally, a mutation in Cav-1 at codon 132 (P132L) was found in 16% of the primary human breast cancer cases [17], and interbreeding Cav1−/− mice with MMTVPyMT mice (mouse mammary tumor virus-Polyoma middle T antigen) accelerated onset of mammary tumors in their offspring [18]. Here, CAV1 is linked to breast cancer.