As damage of DNA not only causes neoplasm but is also utilized in therapeutic interventions such as radiotherapy and chemotherapy, and as Cav-1 is differentially expressed during tumor progression, understanding the role of Cav-1 in DNA DSB repair and the underlying mechanism(s) may help further decipher the signaling pathways involved in tumor initiation and progression, and help develop new approaches to the prevention and treatment of cancers. Here, CAV1 is linked to cancer.