CAV1 and cancer: It has been reported that expression of Cav-1 favors cancer cell proliferation by regulating survival pathways such as Rac, Erk and PtdIns 3-kinase [39] and inhibits detachment-induced apoptosis (anoikis) either through suppressing p53 activation [40] or up-regulating the transcription of the IGF-I receptor gene [41].