CAV1 and neoplasm: The DNA damage-induced Cav-1 up-regulation also occurred in other cell lines (both tumor cells and non-tumor cells) expressing endogenous Cav-1 such as NCI/ADR-RES, T98G and MCF-10A, but not in cell lines (MCF-7 and PC-3) that do not express endogenous Cav-1 (Fig. 1B), and did not appear to result from altered transcription of the Cav-1 gene, because IR did not affect the level of Cav-1 mRNA in MDA-MB-468 and A549 cells with or without silencing of Cav-1, as determined by qRT-PCR (Fig. 2).