Hence we created a dichotomous variable (H5 versus all other sub-haplogroups) and performed again the logistic regression analysis including sex, age and APOE4.Overall sub-haplogroup H5 has a slightly higher AD risk (OR = 2.19, 95%CI  = 1.06–4.51) in the female group than in the total sample (OR = 1.83, 95%CI  = 1.04–3.23). Here, APOE is linked to Alzheimer disease.