The genetic and phenotypic differences between fitful and Dnm1 null mice - in particular, epilepsy in fitful heterozygotes but not in Dnm1 null mice of either genotype ([9]; P. de Camilli, personal comm.; our unpublished observations) – further suggests that DNM1aFtfl protein confers unique properties relevant for disease. This evidence concerns the gene DNM1 and epilepsy.