GHRL and type 2 diabetes mellitus: If it was confirmed that ghrelin ablation restores the first-phase of insulin secretion, as observed in ghrelin knockout ob/ob mice, [36] this could have clinical relevance, because in humans the loss of first-phase insulin secretion is predictive for the development of type 2 diabetes [111]; therefore, in subjects at risk for type 2 diabetes, treatment with a ghrelin antagonist may prove beneficial.