The goal of the current study was to test whether mutant mice lacking GluA1AMPAR subunit exhibit ‘mania-related’ phenotypic abnormalities.Taken together with earlier studies demonstrating that GluA1 KO exhibitschizophrenia- and depression-related phenotypes under certain conditions, thecurrent study suggests that these mice phenocopy features of schizoaffectivedisorder. Here, GRIA1 is linked to depressive symptom measurement.