While the phenotype of locomotor hyperactivity and heightened-approach, atleast in certain tests, displayed by GluA1 KO models positive symptoms inschizophrenia and the manic-like component of schizoaffective disorder, it alsoresembles other neuropsychiatric disorders, including Attention DeficitHyperactivity Disorder (ADHD) (Brigman et al., inpress; Gainetdinov et al., 1999;Powell and Miyakawa, 2006). This evidence concerns the gene GRIA1 and attention deficit-hyperactivity disorder.