Recently, genome-wide association (GWA) studies of asthma have found that variants in or near several genes, including ORMDL3 [MIM 610075] [5-12], CHI3L1 [MIM 601525] [13], TLE4 [MIM 605132] [14], PDE4D [MIM 600129] [15], DENND1B [MIM 613292] [16], RAD50-IL13 [MIM 604040, 147683] [17], and the HLA-DR/DQ region on chromosome 6p21.3 [17], contribute to the risk of asthma. The gene discussed is CHI3L1; the disease is asthma.