Expression microarray profile revealed five genes (TTMA, PTPN2, NDC80, SLMO1 and TUBB6) coordinately deregulated with L3MBTL4 and also localized in an 18p region frequently lost in breast tumors, suggesting a common mechanism of deregulation of their expression, which might contribute to breast oncogenesis. Here, PRELID3A is linked to breast neoplasm.