Interestingly, the expression of the NOD2-C2 transcript in LCLs was significantly different for all three possible rs2076085 genotypes with 2-fold higher expression of the C allele compared to G. The observed allele-preferential expression of NOD2-C2 transcripts allows speculation about potential implications with respect to inflammatory abnormalities like CD. The gene discussed is NOD2; the disease is Cowden disease.