TLR9 and central nervous system cancer: We consider the glioma tissue as an unseperatabe whole, which was consist of glioma cells, infiltrated lymphocytes and microglial cells et al. The expression of TLR9 in different kind of cells within the glioma tissue, but not only in glioma cells, will affect the prognosis of patients with glioma., we think the TLR9 expression may reflect inflammatory microenviroment within glioma tissues.