TLR9 expression in non-tumoral cells or microglia activation may play an important role in the CpG induced anti-cancer immunotherapy, however, the inflammatory response observed following CpG treatment do not always prevent growth of solid tumor masses, in one CpG treated glioma animal model[43], intratumoral application of CpG proved ineffective. The gene discussed is TLR9; the disease is central nervous system cancer.