WEE1 and cancer: Other studies have involved large-scale PCR amplification of exons and subsequent DNA sequence analysis of the amplicons to survey the mutational status of protein kinases in many cancer samples [4], 623 'cancer genes' in lung adenocarcinomas [5], 601 genes in glioblastomas, and all annotated coding sequences in breast, colorectal [6,7] and pancreatic tumors [8], searching for somatic mutations that drive oncogenesis.