TPM2 and autosomal recessive limb-girdle muscular dystrophy type 2A: We therefore proceeded with studying muscle protein homogenates from Calpainopathy patients for their levels of two predicted substrates that represent some of the functional diversity of the predicted substrates: the cytoskeletal protein Tropomyosin (TPM2, MIM*190990), and the myogenic differentiation protein Brother of CDO precursor (BOC, MIM*608708).