CAPN3 and limb-girdle muscular dystrophy: [30] The broad motif makes it unlikely that different CAPN3 mutations cause an LGMD phenotype due to the deregulation of only one or two substrates. Still it will be interesting to see whether mutations in cleavage sites have been described for the uncovered substrates, and with which phenotypic consequences. Of special interest is PIAS3, which is a target for both CAPN3 and TRIM32 (MIM*602290). [35] TRIM32 mutations cause LGMD2H (OMIM#254110), a phenotype similar to LGMD2A. [36] Therefore PIAS regulation may connect two genetically distinct types of LGMD.