Surprisingly, sEH-inhibition by cis-4-[4-(3-adamantan-1-yl-ureido)-cyclohexyloxy]-benzoic acid (cAUCB) had no effect on the development of hypertension, while ACE-inhibition by Ramipril significantly attenuated the process in 5/6-Nx mice at both time points (Fig. 1A). Here, ACE is linked to hypertensive disorder.