Importantly, the compound had a similar effect on the progression of renal failure in 5/6-Nx mice as the sEH inhibitor: It did not affect blood pressure (Fig. 1A) or histological lesion scores (Fig. 2 and 3) but significantly increased albuminuria after 8 weeks of treatment in 5/6-Nx mice (Fig. 1B). The gene discussed is EPHX2; the disease is Renal insufficiency.