BAD and kidney neoplasm: BAD and BCL-2 are all members of BCL-2 gene family, and the role of BAD is to promote apoptosis, BAD genes induced apoptosis through to form heterodimers with BCL-2, thus inhibited the anti-apoptotic role of BCL-2 [3] The researches on gastrointestinal tumors, and kidney tumors have found that high expression of BCL-2 of inhibitor of apoptosis, induced tumor growth accelerated, the poor prognosis and poor response to treatment [4,5].