Kaplan–Meier survival analysis showed significantly reduced disease-free survival (p = 0.016; median survival 13 months) in HNSCC patients harboring increased nuclear expression of S100A7, compared with median disease-free survival of 70 months in the patients showing no nuclear S100A7 immunostaining (Figure 3a). The gene discussed is S100A7; the disease is head and neck squamous cell carcinoma.