In this context, the significant increase in S100A7 expression observed in HNSCCs (67% cases) as compared to the oral leukoplakia lesions with dysplasia (44%) is an important finding of our study (p = 0.005, OR = 2.8, 95% CI = 1.4−5.7), suggesting that nuclear accumulation of S100A7 may be linked to increased risk of malignant transformation and might serve as a marker to identify the high-risk lesions. Here, S100A7 is linked to Oral leukoplakia.