In addition to nuclear staining, intense S100A7 staining was also observed in the cytoplasm of tumor cells in 74 of 100 HNSCC analyzed (p<0.001, OR = 14.9, 95% CI = 7.4−29.9, Table 1 and Figure 1B (iv)). Here, S100A7 is linked to head and neck squamous cell carcinoma.