We analyzed the expression of S100A7/psoriasin in HNSCC, oral lesions (with histological evidence of squamous cell hyperplasia or dysplasia) and non-malignant oral tissues by immunohistochemistry, determined its correlation with clinicopathological parameters, and investigated its utility as a prognostic marker for HNSCC. The gene discussed is S100A7; the disease is head and neck squamous cell carcinoma.