If, in future studies, we can verify that LRP-1 mediates TSP-1 uptake in SMC and that this is modified by hyperglycemia we will be able to determine whether it is the levels of the receptor that differ between normal and high glucose or some other difference that accounts for the change in TSP-1 uptake and more precisely define the mechanism by which glucose regulates TSP-1 uptake and degradation. The gene discussed is LRP1; the disease is Hyperglycemia.