To investigate whether EBV infection correlates with an impairment in JAK/STAT signaling downstream of the IFNα receptor, we first monitored the phosphorylation of Tyk2, Jak1, STAT1 and STAT2 in monocytes infected with EBV alone or infected and restimulated with IFNα. The gene discussed is TYK2; the disease is Epstein-Barr virus infection.