MMP2 and melanoma: Surprisingly, the MMP-2 epitope, located in the C-terminal extremity of the protein, was poorly or not processed by the classical endogenous pathway, since melanoma cells, which secrete MMP-2 but lack αvβ3 integrin expression, and cells that synthesized MMP-2 but do not secrete it, failed to be recognized by the specific CTL clone [9].