Transfection of plasmids encoding the four mutated forms of MMP-2 (MMP-2C60A, MMP-2C65A, MMP-2C60/65A and MMP-2C233A) into the M117 melanoma cell line or the non-small cell lung carcinoma (NSCLC) 1355 cell line, induced activation of the MMP-2- specific CTL clone (Fig. 2). This evidence concerns the gene MMP2 and non-small cell lung carcinoma.