GIGYF2 and Parkinson disease: Although we have not yet uncovered a specific role for the Pyr C-terminus, of note is the fact that the C-terminal domain of Pyr exhibits homology to the intracellular protein human protein Trinucleotide Repeat-Containing 15 (Tnrc15) implicated in Parkinson's disease (18% identity vs. 38% similarity over an approximately 500 aa stretch; data not shown) [49].