The lack of such histological alterations in previous experimental diabetic nephropathy models treated with anti-VEGF antibodies or SU5416 [19-21], and amelioration of diabetic glomerular alterations by inducible podocyte-specific overexpression of sVEGFR-1 in adult mice [64] suggest that anti-VEGF-A therapy might not be detrimental for patients with diabetic nephropathy. The gene discussed is VEGFA; the disease is diabetic kidney disease.