VEGFA and diabetic kidney disease: Because histological 'angiogenic' abnormal vessels in the glomerular capillary area, Bowman's capsule and the glomerular vascular pole are observed in the early stages of diabetic nephropathy in both humans and rodents [24,123,124,127], and the involvement of VEGF-A was demonstrated in the progression of experimental diabetic nephropathy [19,20], we hypothesized that anti-angiogenic factors might inhibit the progression of diabetic nephropathy.