Recently, our studies have found that breast tumor cells are capable of modulating the migration of vascular SMCs in vitro, and this event is mediated through vascular endothelial growth factor (VEGF)/B-form of platelet-derivative growth factor (PDGF-B) - neuropilin-1 (NRP-1) signaling pathways [20,21]. The gene discussed is VEGFA; the disease is breast neoplasm.