Binding of miRNAs or RNA-binding proteins to target sequences in 3' UTRs has been shown to influence translation.(30) For example, Wang and colleagues showed that a risk-conferring polymorphism for Parkinson disease in human populations resides in the 3' UTR for FGF20. The polymorphism is in a binding site for miRNA-433 and increases translation of FGF20 both in vitro and in vivo. This evidence concerns the gene FGF20 and Parkinson disease.