CAPN3 and autosomal recessive limb-girdle muscular dystrophy type 2A: For example, skeletal muscle-specific calpain 3/p94 is a product of the gene responsible for limb-girdle muscular dystrophy type 2A (LGMD2A) [4], demonstrating that the inactivation of tissue-specific calpains is a potential direct strategy for understanding some of the calpain functions.