Tao et al. reported that the prevalence of breast tumor methylation at CDKN2A, CDH1, and RARB did not differ by folate intake or lifetime alcohol consumption in genotype strata of one-carbon metabolism enzymes methylenetetrahydrofolate reductase (MTHFR) and methionine synthase (MTR) [33]. Here, CDKN2A is linked to breast neoplasm.