In array-wide locus-by-locus analysis the strongest associations of methylation of individual loci (Q-values <0.05) were observed for tumor grade (loci n = 209), tumor size (loci n = 74), estrogen receptor status (loci n = 183), progesterone receptor status (loci n = 69), and triple negative status (tumors negative for both estrogen and progesterone receptors as well as ERBB2; loci n = 130; Table S2). The gene discussed is ESR1; the disease is neoplasm.