In addition, hypermethylation of COL1A2 (collagen type I, alpha 2) has been associated with both proliferation and migration activity in bladder cancer [20], LOX is involved in the control of normal collagen deposition [21], and P2RX7 loss has been linked to morphologic changes in stroma related to altered collagen fibril alignment [22]. This evidence concerns the gene COL1A2 and urinary bladder cancer.