Although the IκBα super suppressor is commonly employed to inhibit the activation of the NFκB transcription factors, it is important to note that no significant NFκB activation was observed during early γHV68 infection (within the first 6 hours post-infection) [40], temporal phase in which the critical roles of IKKβ was indentified by our genetic and biochemical experiments. This evidence concerns the gene NFKB1 and infection.