ITGAM and hydrops fetalis: This possibility is consistent with findings from recent studies, which have shown that deletion of toll-like receptor 4 (Tlr4) in hematopoietic cells abrogates HF diet-associated inflammation in liver and adipose tissue [29], and that liver damage due to adoptive transfer of immature myeloid cells (CD11b+Ly6ChiLy6G−) from HF-fed mice occurs only when donor cells carry the gene encoding the Myd88 intracellular adaptor protein [25].