IGHE and asthma: However, after adjusting for potential confounders (sex, ethnicity, current ETS exposure, maternal asthma, prenatal cockroach allergen levels in bed), children with positive cockroach-induced PBMC proliferation had almost 3.4 times increased odds of positive concurrent anti-cockroach IgE (n = 78, OR 3.39, 95% CI 1.05, 10.92) compared to children without positive cockroach-induced PBMC proliferation (Table 4).