BGLAP and Familial prostate cancer: Considering that bone resorption is favorable to tumor growth in bone(18–20) and there is a high tendency of prostate cancer to localize in bone, MKs may indirectly inhibit tumor growth via decreased OC resorption and reduced cytokine and growth factor release from the bone matrix.(15–17) Another possibility is that MKs directly affect prostate cancer cells in their trajectory through the bone marrow microenvironment.