RUNX2 and cleidocranial dysplasia 1: Loss-of-function mutations in RUNX2 cause the autosomal dominant disorder, cleidocranial dysplasia (OMIM 119600), characterized by dysgenesis (or agenesis) of the clavicles and delayed closure of the anterior fontanelle [Mundlos et al., 1997; Cunningham et al., 2006].