Several of them are also implicated in other retinal dystrophies: CRB1, RPE65, RDH12and SPATA7are associated with both LCA and early-onset retinal dystrophy (EORD), which often overlap (Gu et al., 1997; den Hollander et al., 1999; Janecke et al., 2004; Wang et al., 2009). Here, RPE65 is linked to Leber congenital amaurosis.