EGFR and small cell lung carcinoma: The tyrosin kinase inhibitor gefitinib, directed against the tyrosin kinase domain of the EGFR, showed single-agent activity against SCLC cells (Tanno et al, 2004), and reverted resistance to the chemotherapeutic topotecan in vitro (Nakamura et al, 2005), but failed to show clinical benefit in a recent phase II clinical trial in patients with SCLC (Moore et al, 2006).