In our previous work, we found that lycorine decreased the survival rate and inducing apoptosis in leukemia and multiple myeloma cell lines[19,20], and the mechanisms of induced apoptosis have mediated by stimulating the caspase pathway and increasing the Bax:Bcl-2 ratio through the down-regulation of Bcl-2 expression. The gene discussed is BCL2; the disease is plasma cell myeloma.