Here in the present studies, the expressions of p21 were increased by α-santalol treatment in both cell lines; the expressions of mutated p53, that is overexpressed in most of cancer cells [36], were decreased after α-santalol treatment in A431 cells and expressions of wild-type p53 were increased by α-santalol in UACC-62 cells, all of which may contribute to α-santalol's overall chemopreventive effects against skin cancer. The gene discussed is TP53; the disease is skin neoplasm.