To determine whether the FVL mutation impacts on local or systemic activation of coagulation in pneumococcal pneumonia we determined levels of TATc and FDP in lung homogenates (Figures 1a and 1b) and plasma (Figures 1c and 1d) in WT, heterozygous and homozygous FVL mice 24 and 48 hours after intranasal inoculation with viable S. pneumoniae. This evidence concerns the gene OTOR and pneumococcal pneumonia.