Secondly, nude mice with xenograft tumor were randomized into 3 groups as concurrent administration group (rh-endostatin 400 μg·d-1, d1-d35, docetaxel 10 mg·kg-1·3d-1, d1-d19), endo-first group (rh-endostatin 400 μg·d-1, d1-d35, docetaxel 10 mg·kg-1·3d-1, d16-d34) and model group (positive control, mice burdened tumor without treatment). Here, COL18A1 is linked to neoplasm.