Firstly, nude mice with xenograft tumor were randomized into 2 groups as rh-endostatin-treated group with rh-endostatin 400 μg·d-1, d1-d14 and docetaxel-traeted group with docetaxel 10 mg·kg-1·3d-1, d1-d14. The gene discussed is COL18A1; the disease is neoplasm.