EGFR and neoplasm: In a phase II study of 148 patients with EGFR-positive mCRC, grades 2–4 skin toxicity was associated with longer PFS (HR 0.67; 95% CI 0.50 to 0.90) and OS (HR 0.72; 95% CI 0.54 to 0.97) compared with grades 0–1 skin toxicity49.