Mutational analysis of the 80 patients from North India revealed typical missense mutations in exon 4 (Arg124Cys) and exon 12 (Arg555Trp) of TGFBI in most the patients with lattice corneal dystrophy (LCD) and granular corneal dystrophy (GCD), respectively. The gene discussed is TGFBI; the disease is Granular corneal dystrophy.