SQSTM1 and age-related macular degeneration: These findings open new avenues for understanding the mechanisms of proteolytic processes in retinal cells, and could be useful in the development of novel therapies targeting p62 and HSP70 [50-52], or the proteins that regulate lysosomal-mediated proteolysis [52,53], with the aim of preventing retinal cell deterioration during aging such as that occurring in AMD [1].