For example, radiosensitive breast cancer patient 13 had a non-allelic compound pathogenic ATM genotype comprised of a truncating Lys640Stop mutation on one allele and on the other allele a splice site mutation c.1066-6T > G (that caused skipping of exon 11 and premature termination in exon 12 sequence) that reduced transcript stability and the protein level (~10%) but did not result in any of the more severe early-onset A-T pathologies. The gene discussed is ATM; the disease is breast carcinoma.